Open Science

OpenScience is an open-source AI workbench for scientific research developed by Synthetic Sciences. It runs as a browser-based workspace where a single research agent takes a goal through literature review, hypothesis formation, code writing and execution, experiments, analysis, and a written report. The agent can load domain skills, delegate bounded exploratory or execution work, query scientific databases, and preserve sessions as observable research traces. The local server hosts the workspace UI, agent runtime, skill library, and tool layer. The agent plans with a research harness and calls shell, editor, LSP, MCP, scientific database, and skill tools; sessions, skills, artifacts, and provenance are stored on disk. The workbench includes a file tree, code editor, terminal, session history, and inline rendering for molecules, structures, genomes, and plots. Its bundled skills cover training, evaluation, datasets, molecular and clinical biology, cheminformatics, papers and LaTeX, figures, and scientific runtimes, while database connectors provide direct access to services including UniProt, PDB, Ensembl, ChEMBL, PubChem, arXiv, OpenAlex, and Semantic Scholar. It supports frontier and open-weight models through user-provided keys, eligible ChatGPT or Codex access, local models, and optional Ace-managed models. Models are routed per request, allowing providers to be switched without changing the workspace. Extensibility includes LSP integration, MCP servers, plugins, custom agents and commands, experimental Python environments and BioNeMo adapters, and a TypeScript SDK. It is installed with the @synsci/openscience npm package or launched through npx; platform binaries and desktop installers are distributed through GitHub Releases. A free Synthetic Sciences account links an installation and can provide credential synchronization, private research graphs, enhanced search, and optional credit-backed models, while BYOK and local-model usage remain separate from Ace.

OpenResearch is a local-first workspace for research agents and autoresearch, available as a desktop application and a macOS/Linux CLI. It turns Claude Code, Codex, or OpenCode into agents that can review literature, develop hypotheses, run experiments, and produce research artifacts. The workspace assigns independent agent sessions and isolated Git worktrees to parallel research directions. It tracks experiment variants in a Git-native experiment tree, archives each run against its recorded commit, and keeps logs, diffs, files, results, and artifacts tied to the work that produced them. Its autoresearch loop can propose an idea, modify code, launch an experiment, inspect evidence, and choose the next direction. The same committed source snapshot can run locally or through SSH, Slurm, Kubernetes, Ray, Hugging Face Jobs, Modal, Tinker, or managed OpenResearch compute. By default, projects and run data remain on the user's machine in a local SQLite store, with a browser dashboard served on localhost. An OpenResearch account is used for service-owned capabilities such as organizations and managed compute. The CLI also installs an OpenResearch skill into supported coding agents and provides commands for projects, runs, logs, experiments, discovery, and paper lookup.

OpenWorker is an open-source desktop AI coworker that produces finished deliverables from everyday tasks, including code-security reviews with proposed fixes, cloud-configuration audits, incident reports, documents, spreadsheets, drafted messages, and scheduled briefs. It runs on the user's machine through a native desktop app and a local Python agent server built on aisuite, working across local files, the terminal, connected applications, and more than 25 connectors. Specialist coworkers cover security review, cloud posture, incident triage, everyday work, and recurring automations; security review combines deterministic scanners such as Semgrep with model reasoning, then re-scans and diff-reviews proposed fixes before approval. The agent breaks requested outcomes into steps and uses models from providers such as OpenAI, Anthropic, and Google, open-weight providers, or a local Ollama deployment, with the user supplying model access. Consequential actions—including sending messages, changing calendars, and running commands—are approval-gated. Its governance design includes human-only floors for dangerous or irreversible operations, explicitly granted and revocable autonomy rules, circuit-breaker escalation for uncertain or repeatedly denied actions, and an audit trail recording tool calls, approval provenance, and reviewer reasoning; unattended runs cannot self-approve. The project is in open beta and provides downloads for macOS on Apple Silicon and Windows on x64.

ODS is a self-hosted local AI server stack developed by Osmantic for Linux, Windows with WSL2 and Docker Desktop, and Apple Silicon macOS. Its installers detect the host hardware, select an installable model, generate credentials, and launch a preconfigured stack containing local LLM inference, Open WebUI, a management dashboard, LiteLLM, embeddings, speech-to-text, text-to-speech, agents, n8n workflows, Qdrant-based RAG, search, ComfyUI image generation, and operational and privacy tools. Local mode is the default; cloud and hybrid modes can route through OpenAI, Anthropic, or Together APIs. The stack uses a bootstrap model so chat can begin while the hardware-selected full model downloads in the background. A manifest-based extension system discovers service folders and merges their Docker Compose definitions into the stack, while the `ods` CLI manages services, models, modes, configuration, presets, and lifecycle operations. The repository documents GPU and unified-memory paths for NVIDIA, AMD, Intel Arc, and Apple Silicon hardware, along with model selection, recovery, validation, and operator workflows. ODS is distributed as an Apache-2.0-licensed open-source repository and can be installed with shell or PowerShell installers. The repository identifies version 2.6.0 as its stable release and states that no cloud account or subscription is required for local operation.

OpenBot is an open-source AI agent platform from CopilotKit that gives each agent its own computer with a browser, logins, files, tools, and a dedicated interaction channel. It runs in the user's infrastructure and accepts agents that speak the AG-UI protocol, including agents built with LangGraph, Mastra, CrewAI, Pydantic AI, Google ADK, or custom code. A single gateway mediates actions involving the computer, files, MCP servers, and UI components: it decides whether an action is permitted before execution and records it afterward. Agents can operate their own browser screen, hand control to a human for restricted actions, and return component-based responses. Docker Compose runs the application components and PostgreSQL, while the administrator supplies the model credentials; the repository describes the project as alpha software under active development.