OpenHands

OpenHuman is a local-first personal AI system from tinyhumansai that combines persistent memory, agent orchestration, and research tools. It stores a user's data as scored Markdown trees in SQLite on the local machine and mirrors the result to an editable Obsidian vault; its TokenJuice component compresses tool output before it reaches the language model. Its orchestration layer runs checkpointed, durable agent workflows and worker fleets on graphs, with triggers, approvals, steering, halting, and replay support. The system also provides web search, scraping, coding tools, a browser, native voice through in-process Whisper, model routing, messaging integrations, and support for provider keys or fully local Ollama models. The repository describes it as an early beta under active development.

OpenCode is an open-source AI coding agent developed by anomalyco. It is used as a terminal-based coding agent and external coding harness, with a beta desktop application also available. The CLI includes a full-access build agent for development work and a read-only plan agent for code analysis and exploration; the plan agent denies file edits by default and asks permission before running shell commands. OpenCode also provides a general subagent for complex searches and multistep tasks, and can be installed through its shell installer, package managers, or platform-specific desktop packages.

Open Interpreter is a command-line coding agent optimized for open and low-cost models. It is a fork of OpenAI's Codex focused on emulating provider-specific agent harnesses; its Rust-native harnesses can be switched with `/harness`, while providers and models can be changed from its terminal interface. It supports native sandboxing on macOS, Linux, and Windows, MCP, skills, hooks, permissions, AGENTS.md instructions, and local configuration and session state under `~/.openinterpreter`. The agent can run as an Agent Client Protocol agent for compatible editors, speak the Codex exec protocol, and provide a one-line binary override for applications using the Codex SDK. Its built-in QA skill can test web applications through a real browser and native applications through trycua. The project is distributed for macOS, Linux, and Windows through shell or PowerShell installation commands and uses shared agent directories and protocols where available.

OpenScience is an open-source AI workbench for scientific research developed by Synthetic Sciences. It runs as a browser-based workspace where a single research agent takes a goal through literature review, hypothesis formation, code writing and execution, experiments, analysis, and a written report. The agent can load domain skills, delegate bounded exploratory or execution work, query scientific databases, and preserve sessions as observable research traces. The local server hosts the workspace UI, agent runtime, skill library, and tool layer. The agent plans with a research harness and calls shell, editor, LSP, MCP, scientific database, and skill tools; sessions, skills, artifacts, and provenance are stored on disk. The workbench includes a file tree, code editor, terminal, session history, and inline rendering for molecules, structures, genomes, and plots. Its bundled skills cover training, evaluation, datasets, molecular and clinical biology, cheminformatics, papers and LaTeX, figures, and scientific runtimes, while database connectors provide direct access to services including UniProt, PDB, Ensembl, ChEMBL, PubChem, arXiv, OpenAlex, and Semantic Scholar. It supports frontier and open-weight models through user-provided keys, eligible ChatGPT or Codex access, local models, and optional Ace-managed models. Models are routed per request, allowing providers to be switched without changing the workspace. Extensibility includes LSP integration, MCP servers, plugins, custom agents and commands, experimental Python environments and BioNeMo adapters, and a TypeScript SDK. It is installed with the @synsci/openscience npm package or launched through npx; platform binaries and desktop installers are distributed through GitHub Releases. A free Synthetic Sciences account links an installation and can provide credential synchronization, private research graphs, enhanced search, and optional credit-backed models, while BYOK and local-model usage remain separate from Ace.

OpenResearch is a local-first workspace for research agents and autoresearch, available as a desktop application and a macOS/Linux CLI. It turns Claude Code, Codex, or OpenCode into agents that can review literature, develop hypotheses, run experiments, and produce research artifacts. The workspace assigns independent agent sessions and isolated Git worktrees to parallel research directions. It tracks experiment variants in a Git-native experiment tree, archives each run against its recorded commit, and keeps logs, diffs, files, results, and artifacts tied to the work that produced them. Its autoresearch loop can propose an idea, modify code, launch an experiment, inspect evidence, and choose the next direction. The same committed source snapshot can run locally or through SSH, Slurm, Kubernetes, Ray, Hugging Face Jobs, Modal, Tinker, or managed OpenResearch compute. By default, projects and run data remain on the user's machine in a local SQLite store, with a browser dashboard served on localhost. An OpenResearch account is used for service-owned capabilities such as organizations and managed compute. The CLI also installs an OpenResearch skill into supported coding agents and provides commands for projects, runs, logs, experiments, discovery, and paper lookup.