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Enzyme

Enzyme is a local-first compile step and command-line tool for knowledge bases, developed by byenzyme. It compiles Markdown notes and other sources into a local index by sampling context over time, using tags, wikilinks, folders, and dated records to generate thematic questions called catalysts. These catalysts are embedded and used at query time to find relevant documents, giving AI agents an orienting map of a knowledge base without generating full summaries for every search. The tool supports Markdown folders, Apple Notes, Are.na channels, and experimental SQLite message archives, with commands for compiling settings, initializing and refreshing an index, inspecting the resulting concept map, and running hybrid searches that return source passages together with the catalyst connecting them to the query. It can use hosted, local, or OpenAI-compatible models, and can index and search without catalyst generation when no model is configured. Enzyme is licensed under the Apache License 2.0.

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What Enzyme is used for

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  • A compile step for notes that enables AI agents to navigate knowledge bases by building a concept graph from notes and pre-writing thematic questions for searching.

Videos mentioning Enzyme

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